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Jo Callis (born 2 May 1951, Rotherham, Yorkshire) is a musician who played guitar with the Edinburgh based punk rock band, The Rezillos. In 1981, he joined The Human League where he would play both keyboards as well as lead guitar. He also made contributions as a vocalist.

Callis co-wrote many tracks and following his departure from the band in 1986, he has returned several times either to play keyboard, or to offer help with songwriting.